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Post-Graduate Researcher
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Comparative Pathology
The development and application of animal models is a powerful implement to all fields of medical research. A properly designed in vivo system is frequently the only way to create meaningful data in the search for therapeutic and preventative breakthroughs. Recent advancements in the development of transgenic and knockout mice have created an irreplaceable tool in the fight against disease. As a veterinarian and a scientist, it is my goal to utilize this approach in biomedical research and promote the responsible use of animal modeling into the future.
Vector-borne Disease
Rising global temperatures and subsequent expansion of arthropod geographical distributions will undoubtedly lead to an increase in worldwide vector-borne disease. Examining the interface of vector biology, host immunity, and pathogen virulence is critical to the understanding of such diseases. Through the use of animal modeling and molecular techniques, it is my goal to conduct innovative research that will lead to improved diagnostic, preventative, and therapeutic strategies.
Antimicrobial Resistance
The development of antimicrobial drugs is arguably the most significant advancement in medical technology. However, this invaluable resource is under constant threat by misuse and microbial adaptation. Multi-drug resistance is emerging at alarming rates and bacteria have developed resistance to all different classes of antibiotics discovered to date. The need for vigilant surveillance of global resistance patterns is now more important than ever. Furthermore, the development of new drugs and the preservation of existing treatments are critical to the cause. It is my goal to investigate the relevant gene-transfer mechanisms among microbes in an attempt to remain one step ahead of evolving bacterial ecosystems.
The effects of sand fly salivary proteins on the pathogenesis of visceral leishmaniasis in a hamster model.
It has been shown that a protein in sand fly saliva has profound effects on the host, including vasodilation and immune modulation. In addition, vaccination with this protein offers protective immunity in a mouse model of cutaneous disease when challenged with Leishmania major. The aim of this work is to develop and characterize a model of visceral disease in the hamster using vector transmission (Lutzomia longipalpis) of the parasite Leishmania chagasi. This model will be used to analyze the effects of targeted sand fly salivary proteins on the pathogenesis and immune response in the host. Further studies will examine the potential for developing a vaccine based on this approach.
Sero-prevalence of Canine Brucellosis in Grenada.
Studies on the epidemiology, wildlife and domestic animal biology, and the public health importance of Echinococcus granulosus in Uganda.
Bachelor of Science (Biology), University of Missouri, Columbia, 2000
Master of Public Health, St. George’s University, Grenada, West Indies, 2003
Doctor of Veterinary Medicine, St. George's University, Grenada, West Indies, 2005
Ph.D. Student, Comparative Pathology, University of California, Davis, 2006 to present
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